Green Synthesis of Novel Silver Nanoparticles Using Salvia blepharophylla and Salvia greggii: Antioxidant and Antidiabetic Potential and Effect on Foodborne Bacterial Pathogens

Addisie Geremew; John Gonzalles; Elisha Peace; Sela Woldesenbet; Sheena Reeves; Nigel Brooks Jr; Laura Carson

doi:10.3390/ijms25020904

Green Synthesis of Novel Silver Nanoparticles Using Salvia blepharophylla and Salvia greggii: Antioxidant and Antidiabetic Potential and Effect on Foodborne Bacterial Pathogens

Addisie Geremew
, John Gonzalles
, Elisha Peace
, Sela Woldesenbet
, Sheena Reeves
, Nigel Brooks Jr
, Laura Carson

Prairie View A&M University

Prairie View A&M University

Research output: Contribution to journal › Article › peer-review

Abstract

 In the face of evolving healthcare challenges, the utilization of silver nanoparticles (AgNPs)
 has emerged as a compelling solution due to their unique properties and versatile applications. The
 aim of this study was the synthesis and characterization of novel AgNPs (SB-AgNPs and SG-AgNPs,
 respectively) using Salvia blepharophylla and Salvia greggii leaf extracts and the evaluation of their
 antimicrobial, antioxidant, and antidiabetic activities. Several analytical instrumental techniques
 were utilized for the characterization of SB-AgNPs and SG-AgNPs, including UV–visible (UV-Vis)
 spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transmission
 infrared (FT-IR) spectroscopy, energy-dispersive X-ray analysis (EDX), and X-ray diffraction
 (XRD). FTIR analysis identified various functional groups in the leaf extracts and nanoparticles,
 suggesting the involvement of phytochemicals as reducing and stabilizing agents. High-resolution
 TEM images displayed predominantly spherical nanoparticles with average sizes of 52.4 nm for
 SB-AgNPs and 62.5 nm for SG-AgNPs. Both SB-AgNPs and SG-AgNPs demonstrated remarkable
 antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and Listeria monocytogenes
 and Gram-negative bacteria Salmonella typhimurium and Escherichia coli. SB-AgNPs and SG-AgNPs
 also exhibited 90.2 ± 1.34% and 89.5 ± 1.5% DPPH scavenging and 86.5 ± 1.7% and 80.5 ± 1.2%
 α-amylase inhibition, respectively, at a concentration of 100 μg mL−1. Overall, AgNPs synthesized
 using S. blepharophylla and Salvia greggii leaf extracts may serve as potential candidates for antibacterial,
 antioxidant, and antidiabetic agents. Consequently, this study provides viable solutions to
 mitigate the current crisis of antibiotic resistance and to efficiently combat antimicrobial infections
 and Type 2 diabetes.

Original language	American English
Journal	Int. J. Mol. Sci.
Volume	25
DOIs	https://doi.org/10.3390/ijms25020904
State	Published - Jan 11 2024

Keywords

Salvia blepharophylla; Salvia greggii; antioxidant; antidiabetic; antibacterial; foodborne pathogens

Disciplines

Life Sciences
Biology
Food Science
Nutrition
Pharmacology, Toxicology and Environmental Health
Medicine and Health Sciences
Alternative and Complementary Medicine
Chemicals and Drugs
Nanomedicine

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10.3390/ijms25020904License: Unspecified

Cite this

@article{3f9c7d80728e48ad9264ddc770736917,

title = "Green Synthesis of Novel Silver Nanoparticles Using Salvia blepharophylla and Salvia greggii: Antioxidant and Antidiabetic Potential and Effect on Foodborne Bacterial Pathogens",

abstract = " In the face of evolving healthcare challenges, the utilization of silver nanoparticles (AgNPs) has emerged as a compelling solution due to their unique properties and versatile applications. The aim of this study was the synthesis and characterization of novel AgNPs (SB-AgNPs and SG-AgNPs, respectively) using Salvia blepharophylla and Salvia greggii leaf extracts and the evaluation of their antimicrobial, antioxidant, and antidiabetic activities. Several analytical instrumental techniques were utilized for the characterization of SB-AgNPs and SG-AgNPs, including UV–visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transmission infrared (FT-IR) spectroscopy, energy-dispersive X-ray analysis (EDX), and X-ray diffraction (XRD). FTIR analysis identified various functional groups in the leaf extracts and nanoparticles, suggesting the involvement of phytochemicals as reducing and stabilizing agents. High-resolution TEM images displayed predominantly spherical nanoparticles with average sizes of 52.4 nm for SB-AgNPs and 62.5 nm for SG-AgNPs. Both SB-AgNPs and SG-AgNPs demonstrated remarkable antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and Listeria monocytogenes and Gram-negative bacteria Salmonella typhimurium and Escherichia coli. SB-AgNPs and SG-AgNPs also exhibited 90.2 ± 1.34\% and 89.5 ± 1.5\% DPPH scavenging and 86.5 ± 1.7\% and 80.5 ± 1.2\% α-amylase inhibition, respectively, at a concentration of 100 μg mL−1. Overall, AgNPs synthesized using S. blepharophylla and Salvia greggii leaf extracts may serve as potential candidates for antibacterial, antioxidant, and antidiabetic agents. Consequently, this study provides viable solutions to mitigate the current crisis of antibiotic resistance and to efficiently combat antimicrobial infections and Type 2 diabetes.",

keywords = "Salvia blepharophylla; Salvia greggii; antioxidant; antidiabetic; antibacterial; foodborne pathogens",

author = "Addisie Geremew and John Gonzalles and Elisha Peace and Sela Woldesenbet and Sheena Reeves and \{Brooks Jr\}, Nigel and Laura Carson",

note = "In the face of evolving healthcare challenges, the utilization of silver nanoparticles (AgNPs) has emerged as a compelling solution due to their unique properties and versatile applications. The aim of this study was the synthesis and characterization of novel AgNPs (SB-AgNPs and SG-AgNPs, respectively) using Salvia blepharophylla and Salvia greggii leaf extracts and the evaluation of their antimicrobial, antioxidant, and antidiabetic activities.",

year = "2024",

month = jan,

day = "11",

doi = "10.3390/ijms25020904",

language = "American English",

volume = "25",

journal = "Int. J. Mol. Sci.",

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TY - JOUR

T1 - Green Synthesis of Novel Silver Nanoparticles Using Salvia blepharophylla and Salvia greggii: Antioxidant and Antidiabetic Potential and Effect on Foodborne Bacterial Pathogens

AU - Geremew, Addisie

AU - Gonzalles, John

AU - Peace, Elisha

AU - Woldesenbet, Sela

AU - Reeves, Sheena

AU - Brooks Jr, Nigel

AU - Carson, Laura

N1 - In the face of evolving healthcare challenges, the utilization of silver nanoparticles (AgNPs) has emerged as a compelling solution due to their unique properties and versatile applications. The aim of this study was the synthesis and characterization of novel AgNPs (SB-AgNPs and SG-AgNPs, respectively) using Salvia blepharophylla and Salvia greggii leaf extracts and the evaluation of their antimicrobial, antioxidant, and antidiabetic activities.

PY - 2024/1/11

Y1 - 2024/1/11

N2 - In the face of evolving healthcare challenges, the utilization of silver nanoparticles (AgNPs) has emerged as a compelling solution due to their unique properties and versatile applications. The aim of this study was the synthesis and characterization of novel AgNPs (SB-AgNPs and SG-AgNPs, respectively) using Salvia blepharophylla and Salvia greggii leaf extracts and the evaluation of their antimicrobial, antioxidant, and antidiabetic activities. Several analytical instrumental techniques were utilized for the characterization of SB-AgNPs and SG-AgNPs, including UV–visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transmission infrared (FT-IR) spectroscopy, energy-dispersive X-ray analysis (EDX), and X-ray diffraction (XRD). FTIR analysis identified various functional groups in the leaf extracts and nanoparticles, suggesting the involvement of phytochemicals as reducing and stabilizing agents. High-resolution TEM images displayed predominantly spherical nanoparticles with average sizes of 52.4 nm for SB-AgNPs and 62.5 nm for SG-AgNPs. Both SB-AgNPs and SG-AgNPs demonstrated remarkable antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and Listeria monocytogenes and Gram-negative bacteria Salmonella typhimurium and Escherichia coli. SB-AgNPs and SG-AgNPs also exhibited 90.2 ± 1.34% and 89.5 ± 1.5% DPPH scavenging and 86.5 ± 1.7% and 80.5 ± 1.2% α-amylase inhibition, respectively, at a concentration of 100 μg mL−1. Overall, AgNPs synthesized using S. blepharophylla and Salvia greggii leaf extracts may serve as potential candidates for antibacterial, antioxidant, and antidiabetic agents. Consequently, this study provides viable solutions to mitigate the current crisis of antibiotic resistance and to efficiently combat antimicrobial infections and Type 2 diabetes.

AB - In the face of evolving healthcare challenges, the utilization of silver nanoparticles (AgNPs) has emerged as a compelling solution due to their unique properties and versatile applications. The aim of this study was the synthesis and characterization of novel AgNPs (SB-AgNPs and SG-AgNPs, respectively) using Salvia blepharophylla and Salvia greggii leaf extracts and the evaluation of their antimicrobial, antioxidant, and antidiabetic activities. Several analytical instrumental techniques were utilized for the characterization of SB-AgNPs and SG-AgNPs, including UV–visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transmission infrared (FT-IR) spectroscopy, energy-dispersive X-ray analysis (EDX), and X-ray diffraction (XRD). FTIR analysis identified various functional groups in the leaf extracts and nanoparticles, suggesting the involvement of phytochemicals as reducing and stabilizing agents. High-resolution TEM images displayed predominantly spherical nanoparticles with average sizes of 52.4 nm for SB-AgNPs and 62.5 nm for SG-AgNPs. Both SB-AgNPs and SG-AgNPs demonstrated remarkable antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and Listeria monocytogenes and Gram-negative bacteria Salmonella typhimurium and Escherichia coli. SB-AgNPs and SG-AgNPs also exhibited 90.2 ± 1.34% and 89.5 ± 1.5% DPPH scavenging and 86.5 ± 1.7% and 80.5 ± 1.2% α-amylase inhibition, respectively, at a concentration of 100 μg mL−1. Overall, AgNPs synthesized using S. blepharophylla and Salvia greggii leaf extracts may serve as potential candidates for antibacterial, antioxidant, and antidiabetic agents. Consequently, this study provides viable solutions to mitigate the current crisis of antibiotic resistance and to efficiently combat antimicrobial infections and Type 2 diabetes.

KW - Salvia blepharophylla; Salvia greggii; antioxidant; antidiabetic; antibacterial; foodborne pathogens

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U2 - 10.3390/ijms25020904

DO - 10.3390/ijms25020904

M3 - Article

C2 - 38255978

VL - 25

JO - Int. J. Mol. Sci.

JF - Int. J. Mol. Sci.

ER -

Green Synthesis of Novel Silver Nanoparticles Using Salvia blepharophylla and Salvia greggii: Antioxidant and Antidiabetic Potential and Effect on Foodborne Bacterial Pathogens

Abstract

Keywords

Disciplines

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